Natural products offers an excellent strategy toward identifying novel biological probes for a number of diseases. Historically, natural products have played an important role in the development of pharmaceutical drugs for a number of diseases including cancer and infection. However, natural products also have the potential to identify novel agents for other complex CNS disorders such as anxiety, chronic pain, depression, and schizophrenia. Unfortunately, it is relatively rare for natural products to have sufficiently attractive absorption, disposition, metabolism and excretion properties despite their attractive potency and selectivity.
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