Organocatalysis uses small organic molecules predominantly composed of C, H, O, N, S and P to accelerate chemical reactions. The advantages of organocatalysts include their lack of sensitivity to moisture and oxygen, their ready availability, low cost, and low toxicity, which confers a huge direct benefit in the production of pharmaceutical intermediates when compared with metal catalysts. Organocatalytic reactions affording achiral compounds opened unexplored pathways in the synthesis of densely functionalized aromatic moieties, olefins and useful molecules such as natural substances.
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